Medications That Interfere With Allergy Testing

Many common medications, especially antihistamines, interfere with allergy skin testing. Antihistamines are in many over-the-counter medications for allergies, colds and sinus problems.  It is important to stop taking these medications at least 5 full days prior to your visit so that skin testing can be performed at your appointment.

If you are currently experiencing significant skin symptoms such as hives (urticaria) or swelling (angioedema), or if you were put on antihistamines for a severe allergic reaction (anaphylaxis), DO NOT STOP your antihistamines without contacting our office at 518-434-1446.

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H1 Antihistamines (Oral/Eye Drops) – Stop taking 5 full days before visit.

Allegra (Fexofenadine)


Unisom (Doxylamine)

Eye Drops

Benadryl (Diphenhydramine)

Tavist (Clemastine)

Vistaril (Hydroxyzine)

Optivar Eye Drops (Azelastine)

Claritin (Loratadine)

Tylenol Allergy Sinus

Atarax (Hydroxyzine)

Elestat Eye Drop

Clarinex (Desloratadine)

Tylenol Flu Nighttime



Eye Drops (Olopatadine)

Zyrtec (Cetirizine)

Tylenol Cold and Flu

Actifed (Triprolidine)

Zaditor (Ketotifen)      

Xyzal (Levocetirizine)




Cyproheptadine (Periactin)

Dramamine (Dimenhydrinate)



Sleep Aids/Cold & Flu Medications: Many OTC medications contain antihistamines – Check for Diphenhydramine or “PM”

H1 Antihistamine Nasal Sprays – Stop taking 2 days before visit.

Astelin/Astepro (azelastine)


Patanase (Olopatadine)


H2 Blocking Medications (Reduces Stomach Acid) – Stop taking 2 days before visit.

Pepcid (Famotidine)

Tagamet (Cimetidine)

Asthma Inhalers and Singulair (Montelukast) do NOT interfere with testing.  Continue taking these medications as prescribed.

Corticosteroid Nasal Sprays do NOT interfere with testing and should be continued.

Flonase (Fluticasone)

Nasacort (Triamcinolone)

Omnaris (Ciclesonide)   


Nasonex (Mometasone)


Rhinocort (Budesonide)

Veramyst/Flonase Sensimist

Other Medications – Other types of medication may interfere with skin testing. DO NOT DISCONTINUE THEM UNLESS INSTRUCTED BY A HEALTHCARE PROVIDER. Our physician will discuss the appropriate diagnostic approach to your case at your visit.

Anafranil (Clomipramine)

Compazine (Prochlorperazine)

Pamelor (Nortriptyline)

Tofranil (Imipramine)

Alprazolam (Xanax)


Phenergan (Promethazine)


Asendin (Amoxapine)

Elavil (Amitriptyline)

Seroquel (Quetiapine)

Vistaril (Protriptyline)

Clonazepam (Klonopin)

Norpramin (Desipramine)

Sinequan (Doxepin)